This empirical research examines the normalized difference vegetation index (NDVI) and the percent impervious surface area (%ISA) as indicators of urban heat island (UHI) effects, using the relationships between land surface temperature (LST), %ISA, and NDVI. Landsat 8 Operational Land Imager and Thermal Infrared Sensor data were used to estimate the LST in Connecticut at different times. A map of the percent impervious surface was generated using the Impervious Surface Analysis Tool developed by the Center for Land Use Education and Research and distributed through the National Oceanic and Atmospheric Administration. Strong linear relationships between LST and %ISA exist, as stated in previous studies, whereas the relationship between LST and NDVI is evidently affected by the seasons. As the patterns of LST in urban areas are influenced by the UHI, the results demonstrate that %ISA is a more reliable indicator of UHI effects than NDVI. Thus, %ISA could be a promising alternative for use in the quantitative analysis of LST when studying UHI effects.